Thursday, January 3, 2008

Medulloblastoma Staging

Based on what the surgeon sees at the time of the surgery, the actual tumor is placed in one of the following categories (T referring to tumor):

T1 Tumor <3>3 cm in diameter
• T3a Tumor >3 cm in diameter with spread

• T3b Tumor >3 cm in diameter with definite spread into the brain stem (part of brain that controls breathing, hearing, seeing, and other important functions)

• T4 Tumor >3 cm in diameter with extension up past the aqueduct of Sylvius and/or down past the foramen magnum

In addition to "T" staging, medulloblastoma staging has been modified by including "M" staging, where the "M" stands for metastasis. Remember, this is a word that describes how far the tumor cells have spread from the original location, if at all. The M stage is determined not only by the surgeon's observations, but also in combination with MRI scans and lumbar cytology, and consists of 5 possible groups:

• M0 No evidence of metastasis
• M1 Tumor cells found in cerebrospinal fluid (by lumbar puncture and cytology study)
• M2 Tumor beyond primary site but still in brain
• M3 Tumor deposits ("seeds") in spine area that are easily seen on MRI
• M4 Tumor spread to areas outside the CNS (outside both brain and spine)